Aspergillus nidulans is a multicellular, filamentous fungus that divides by the formation of a crosswall called a septum. Septum formation is temporally and spatially regulated by nuclear positioning and cell cycle progression. sep G was identified as a conditional mutant that causes an aseptate phenotype in cells that have completed several rounds of mitosis. The sepG mutant is unable to form septa but displays no defects in growth or nuclear division producing long multinucleate hyphae at the restrictive temperture. The sepG gene has been cloned by complementation of the mutant with a chromosome specific library of A. nidulans. Sequencing and further characterization of the gene is underway. sepG is likely to be part of a signaling pathway mediating actin ring formation, the first event of septum formation.
Fungal Genet. Newsl. 46 (Supl):
Full conference title:
Fungal Genetics Conference 20th
- Fungal Genetics Conference 20th (1999)