Sensitization of Moderate to Severe Persistent Pediatric Asthmatics to Various Aeroallergens and its Relationship with Severity of Asthma and Treatment Outcome- Preliminary Study

J.K. Wadhwa, S.K. Kabra, R. Lodha, M.K. Agarwal

Author address: 

All India Institute Of Medical Sciences, New Delhi, INDIA, Vallabhbhai Patel Chest Institute, University of Delhi, Delhi, INDIA


RATIONALE: In view of scarce data from India, we studied sensitization of pediatric asthmatics to some clinically important aeroallergens and its relationship with asthma severity and treatment outcome. METHODS: Fifty four children (5-15 years, mean 9.5 ±2, M: F = 1.8: 1), with moderate to severe persistent asthma were studied. Clinical details, pulmonary function tests (PFT) were recorded at baseline. Skin prick test (SPT) response to 12 common aeroallergens was evaluated. Children were treated with standard anti-asthma medications (NAEPP guidelines). Their treatment response, PFT was recorded after every 2 months for 6 months. Severity of asthma, frequency of exacerbation and treatment outcome was studied between sensitized and non-sensitized asthmatics. Study protocol was approved by Institutional Ethics Committee. Written, informed consent was obtained from parents. RESULTS: Of 54 children, 32 (59.2%) had positive SPT response. Sixteen patients each were SPT positive to only one and more than one allergen extracts. SPT positivity to different aeroallergens was: rice dust (22%), cockroach (18.5%), mosquito (18.5%), housefly(16.6%), house dust mite (15%), Aspergillus tamarii (12%), Alternaria sp (12%), Holoptelea sp (9%), Prosopis juliflora (6%), Cyanodon dactylon (3%), Curvularia sp (3%) and dog dander (3%). No significant difference was obtained with asthma severity, number of exacerbations and treatment outcome between sensitized and non sensitized asthmatics. CONCLUSION: Allergen sensitization did not have any significant impact on pharmacotherapy response in pediatric asthmatics

abstract No: 


Full conference title: 

American Academy of Allergy Asthma & Immunology
    • AAAAI 2010 (66th)