Sensitization to Alternaria as a potential risk factor for Chronic Rhinosinusitis

G.L. Sussman

Author address: 

University of Toronto, Toronto, ON, CANADA.


RATIONALE: Chronic rhinosinusitis (CRS) is a major cause of morbidity in North America, however, the etiology remains poorly defined. Hypersensitivity to fungi, in particular Alternaria, has been proposed to have a putative role. In this study, our objective was to characterize skin prick test (SPT) and human serum reactivity to other common aeroallergens in CRS patients. METHODS: One hundred and thirty two subjects (18-65 years of age) were recruited into the study. 101 subjects had a confirmed diagnostic history of CRS and 31 subjects were recruited as controls. Enrolled subjects underwent SPT to a panel of perennial, grass, weed, tree, and fungal aeroallergens. A blood sample was collected by venipuncture for hematological analysis. Atopic status to selected common environmental allergens (grass, mold, and tree species) was determined using Phadia ImmunoCap. Specific-IgG was also quantified to Cladosporium herbarum, Alternaria alternata, Stachybotrys atra, and Aspergillus versicolor. Differences between CRS and control patients were determined by analysis of variance (ANOVA) and chi-squared analysis. RESULTS: No statistically significant differences were observed between mean specific IgE and IgG titers in CRS and control patients in the ANOVA analysis. Chi-squared analysis of SPT data revealed similar statistically insignificant results, however, positive SPT reactivity to Alternaria was identified as a risk factor for having CRS (OR 3.58, p

abstract No: 


Full conference title: 

American Academy of Allergy Asthma & Immunology
    • AAAAI 2010 (66th)