Screening of melanin from Aspergillus fumigatus for its antibacterial and antifungal activity against clinically isolated strains

Nitva Meenakshi R* and Suganthi R

Author address: 

School of Biotechnology, Dr. G R Damodaran College, Civil Aerodrome Post, Avinashi Road, Coimbatore-641 014

Abstract: 

The search for combinations of drugs is widely recognized as being of the utmost importance in the quest for therapy. In the present study, we have undertaken an evaluation of melanin isolated from A. fumigatus for its antimicrobial activity. We have also assessed any interactions if present with respect to activity against clinically isolated bacterial and fungal strains of melanin in combination with antibacterial and antifungal drugs. MIC values when compared between the drug and combinatorial assay were found to be synergistic and similar values were obtained with synthetic and extracted melanin. These values when compared with the sensitivity of the drug were found to be on par with the international susceptibility readings. Therefore, it can be concluded that melanin can be said to possess antimicrobial activity when found to be used with various agents. Although, further analysis is to be conducted, these results show that melanin when administered or present in the host, the host defenses also have a role to play in enhancing the immunity of the host. The same can be attributed to A. fumigatus in which melanin is a part of the conidia; therefore making this fungus to be potent in its clinical epidemiology. 9830;Corresponding author E-mail:[email protected]
2014

abstract No: 

OP-025

Full conference title: 

Society for Indian Human and Animal Mycologists 2014
    • SIHAM