Screening of Iranaian medicinal plants for anti-Candida activity

Naeini, A.

Author address: 

Shahed University, TEHRAN, Iran

Abstract: 

Background: Candida albicans is the most cause of primary or opportunistic infections which as candidiasis. Recently fungal infections especially candidiasis have significantly increased. Limitations in treatment of fungal diseases include a few available anti-fungal drugs, side effects, drug resistance and decreased susceptibility of candida species to anti- fungal drugs, leads to search for new anti-fungal agents as herbal medicines. Methods: 11 essential oils and 172 plant extracts, from 50 Iranian plant species obtained through the literature and interviews with traditional healers, were evaluated for anti-candida activity. The essential oils and extracts were tested by well diffusion and broth macrodilution method, against candida albicuns (ATCC=10231). Amphotericin B and Nistatin were used as positive controls. Results: Ten (20%) out of the 50 plants were found to be active. The essential oils of thymus kotschyanus, Zataria multiflora Boiss, pimpinella anisum, cumunum cyminum showed high strong activity. The essential oils of Hyssopus officinalis and Artemisia sieberi showed strong activity. Extracts of zataria multiflora Boiss, Allium Haemanthoides showed a good anti-candida activity. Conclusion: The results of this showed a potent anti-fungal activity of selected herbs against candida albicans type strain. Therefore further investigation need in order to isolate and identify the active compounds to make it available for clinical use. Key words: Herbal medicine, candida albicans, anti-candida
2007

abstract No: 

P011

Full conference title: 

3rd Trends in Medical Mycology
    • TIMM 3rd (2011)