Scedosporium species (Sspp) in patients with cystic fibrosis (CF): Implications for clinical practice

Daniel Smith, Timothy Kidd, Kay Ramsay, Szeanna Tai, Scott Bell.

Author address: 

Deapartment of Thoracic Medicine, The Prince Charles Hospital, Brisbane, Queensland, Australia 2School of Medicine, University of Queensland, Brisbane, Queensland, Australia

Abstract: 

Introduction. Sspp are saprophytic fungi found predominantly in soil and contaminated water. They are the second most commonly recovered fungus from the sputum of CF patients. Debate remains whether Sspp are transient airway coloniser, or a cause of disease in CF patients. We report the clinical correlates associated with the isolation of Sspp in attendees to The Prince Charles Hospital (TPCH) adult CF centre between 2001 -2008. Methods. Attendees who isolated Sspp in a sputum sample were identified from the Pathology Database. Demographics including, age, gender, FEV1 at 1st isolate, FEV1 1 year pre- and post- 1st isolate, co-pathogens and co-morbidities were recorded. Results. 27 distinct episodes of Sspp isolation occurred in 21 patients (prevalence 6.2%). 12 single isolates, 11 recurrent isolates (sputum negative for >1year following >1 positive isolate), and 4 chronic infections, including 1 patient with recurrent isolates from tracheal aspirates after liver transplantation. Anti-fungal therapy was initiated in 1 case with severe pulmonary disease where there was uncertainty about the pathological organism. Conclusion. Sspp are isolated in a minority of patients with CF, often with multiple co-pathogens. Sspp may recur and have consequences post-transplantation.
2010

abstract No: 

E3498

Full conference title: 

20th European Respiratory Society conference
    • ERS 20th (2010)