RRMA, an RNA binding protein involved in regulated mRNA degradatio

Kinga Krol[1] Igor Y. Morozov[2] Piotr Weglenski[1] Massimo Reverberi[3] Mark X. Caddick[2] Agnieszka Dzikowska[1]

Author address: 

1Institute of Genetics and Biotechnology, University of Warsaw, Poland, 2School of Biological Sciences, The University of Liverpool, UK, 3Plant Biology, Universita La Sapienza, Roma, Italy


RRMA is the RNA binding protein involved in posttranscriptional regulation of gene expression in Aspergillus nidulans. rrmA gene was identified as a suppressor of mutations in arginine/proline catabolic pathway. Independently RRMA protein was shown to bind to the 3’UTR of areA transcript (nitrogen positive regulator). 916;rrmA mutation results in slow growth phenotype and higher sensitivity to oxidative stress. Analysis of main antioxidant enzymes revealed different activity pattern during early development stages in 916;rrmA strain comparing to the control strain. Transcriptional analysis has shown that 916;rrmA mutation results in higher stability of specific transcripts under conditions of oxidative stress and nitrogen starvation. Our results indicate that RRMA plays important role in metabolism of A. nidulans and can be involved in the mechanism of regulated degradation of specific mRNAs in response to environmental signals

abstract No: 


Full conference title: 

    • ECFG 10th (2010)