Purpose: Although patients with chronic lymphocytic leukemia (CLL) typically respond to available front-line chemotherapy, the response is often temporary, and patients frequently undergo relapse. The authors report the beneficial clinical activity and tolerability of an immunochemotherapeutic regimen consisting of rituximab added to cyclophosphamide, vincristine and prednisolone (R-CVP), in patients with heavily pretreated CLL. Methods: The therapeutic regimen consisted of: cyclophosphamide 750mg/m2 iv on day one, vincristine 1.4mg/m2 iv on day one and prednisolone 100mg po for five consecutive days every 4 weeks, combined with rituximab at a dose of 375mg/m2 on day 1 of each cycle. Patients were evaluated after three cycles, with responding patients receiving up to eight cycles. No infectious prophylaxis was administered. Results: Five patients have been treated with R-CVP: median age 65 years (range 5268), advanced Binet stage (four stage C and one stage B) and heavily pretreated (range 13 prior therapies). All patients received at least three cycles of R-CVP. Clinical and hematological response was achieved in two patients. Three patients had stable disease. One patient was re-induced once after disease progression. Data from a median follow-up of 112 months (range 52128 months) showed that three patients remained free of disease progression 8 months after the first cycle of R-CVP (range 214 months). The principle treatment complication was pulmonary aspergillosis. Conclusion: These promising results suggest salvage therapy with R-CVP is beneficial in patients with heavily pretreated CLL.
Full conference title:
47th American Society for Haematology
- ASH 47th (2005)