Risk Factors for Initial Low Voriconazole Trough Level in Routine Therapeutic Drug Monitoring

S-H. Kim, J-C. Kwon, H-J. Lee, S-Y. Cho, J-K. Choi, C. Park, D-G. Lee, S-M. Choi, J-H. Choi, J-H. Yoo

Author address: 

Pohang Univ. of Sci. and Technology, Pohang, KOREA, REPUBLIC OF, Coll. of Med., The Catholic Univ. of Korea, Seoul, KOREA, REPUBLIC OF, Vaccine Bio Res. Inst., Coll. of Med., The Catholic Univ. of Korea, Seoul, KOREA, REPUBLIC OF, Catholic Res. Inst.

Abstract: 

Background: It is known that low voriconazole levels are related to treatment failure in patients with invasive aspergillosis. The purpose of this study is to identify risk factors for initial low voriconazole trough level in routine therapeutic drug monitoring (TDM). Methods: In this prospective observational study, we analyzed all consecutive adult patients with hematologic disease who received intravenous or oral voriconazole in recommended dosage for treatment of invasive aspergillosis between January 2011 and June 2012. Serum voriconazole trough levels were measured by liquid chromatography[[Unable to Display Character: 8210;]]tandem mass spectrometry method. Initial trough level of
2013

abstract No: 

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Full conference title: 

53rd Interscience Conference on Antimicrobial Agents and Chemotherapy
    • ICAAC, 53rd (2013)