Risk factors for allergic bronchopulmonary aspergillosis in paediatric patients with cystic fibrosis

Chris O'Brien, Jennifer Bird, Samantha Moss

Author address: 

1Department of Respiratory Paediatrics, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle, Tyne and Wear, United Kingdom


Allergic Bronchopulmonary Aspergillosis (ABPA) is increasingly prevalent in cystic fibrosis (CF) patients. Atopy, sex, season at diagnosis and CFTR mutation are suggested risk factors for ABPA. This retrospective case-control study assessed potential risk factors for ABPA, in particular intravenous antibiotic use. Of 150 paediatric patients, 13 fulfilled the CF Foundation consensus diagnostic criteria for ABPA. These were compared to 130 patients without ABPA. The intravenous antibiotic data for the ABPA group was compared to 80 patients without ABPA matched by age at diagnosis. The data collected included age, sex, CFTR mutation, atopy, season of diagnosis and weeks of IV antibiotics administered. The median duration of use of intravenous anti-pseudomonal antibiotics in the ABPA group was 38 weeks, compared to 5 weeks in the non-ABPA group (p

abstract No: 


Full conference title: 

20th European Respiratory Society conference
    • ERS 20th (2010)