The rising tide of fungal genetics: a perspective from the FGSC

Kevin McCluskey, Aric Wiest, Michael Plamann

Author address: 

Fungal Genetics Stock Center, University of Missouri- Kansas City, Kansas City, United State

Abstract: 

As we approach the post genomics age the number of fungal organisms which can call themselves genetic systems continues to grow. Because of this, the number of organisms in the Fungal Genetics Stock Center collection has expanded to include most strains that have had their genomes sequenced as well as genome associated libraries for a number of organisms. As more fungal systems are amenable to genetic research new researchers have come into the field. This has led to an increase in the number of requests for materials from the FGSC including knock-out strains of Neurospora, cloning vectors and strains of sequenced organisms. These increases include numerous people who previously did not use filamentous fungi in their research. Overall we have seen over thirty seven percent increase in orders in 2007 as compared to the average of the eight previous years. This number does not include the nearly 32,000 knockout strains sent in 96-well arrays. Including these, the increase is on the order of 2,300 percent. While most of these are Neurospora, the FGSC has also received knockouts of Cryptococcus and tagged integration mutants of Magnaporthe. In total, we hold over 53,000 knockout or tagged mutants in 96-well format. Beyond fungal strains, the FGSC holds and distributes gene libraries and individual clones from genome-mapped libraries for many of the main organisms used in genetic research. Using these resources, we have identified the underlying mutation for several temperature sensitive mutants in Neurospora crassa. We are endeavoring to develop useful applications of these findings in Neurospora and Aspergillus.
2008

abstract No: 

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Full conference title: 

9th EUROPEAN CONFERENCE ON FUNGAL GENETICS
    • ECFG 9th (2008)