Rhinocerebral Mucormycosis as the First Presentation of Diabetes Mellitus in a 48 Year- Old-Woman

F. Abbasi, M. Aghahasani, K. Aghazadeh Sarhangipour, S. Korooni Fardkhani

Author address: 

Shaheed Beheshti Medical University, TEHRAN, Iran


Background: Rhinocerebral mucormycosis is a devastating, rapidly progressive and often fatal opportunistic fungal infection predominantly affecting individuals with underlying metabolic or immunological compromise. Patients: We presented a case of rhinocerebral mucormycosis as first presentation of diabetes mellitus. She had negative history of DM, presentented with coryza, erythema and swelling of left periorbital area one week before admission. Symptoms progressed quickly and she developed ptosis and chemosis and epistaxis. Paranasal CT scan showed destrauction of left and right maxillary sinuses with exention to other sinuses, nose, orbit and base of skull. Operation was done. Orbital exenteration, debridment of intranasal mocus membrane and necrotic tissue was done. Despite extensive surgical debridment and medical therapy the patient expired. Conclusion: The diagnosis of rhinocerebral mucormycosis should be considered in the clinical setting of necrotic sinusitis and acute neurologic deficit in diabetic patients. Early diagnosis and treatment are crucial factors leading to a good outcome. Key words: mucormycosis, rhinocerebral, amphitericin-B, diabetes mellitus

abstract No: 


Full conference title: 

4th Trends in Medical Mycology
    • TIMM 4th (2012)