Respiratory virus infections other than in64258; uenza virus in allogeneic stem cell transplant recipients

M. Tsuji (1), H. Araoka (1), A. Wake (2), A. Nishida (1), H. Ohta (1), H. Shimazu (1), K. Ishiwata (1), N. Nakano (1), H. Yamamoto (1), Y. Asano-Mori (1), K. Izutsu (1), N. Uchida (1), A. Yoneyama (1), H. Nishimura (3), M. Saijo (4), S. Taniguc

Author address: 

(1)Toranomon Hospital (Tokyo, JP); (2)Toranomon Hospital Kajigaya (Kanagawa, JP); (3)Sendai Medical Center (Miyagi, JP); (4)National Institute of Infectious Diseases (Tokyo, JP)

Abstract: 

Background: Respiratory virus infections following allogeneic stem cell transplantation (alloSCT) have been sometimes associated with mortality and morbidity. We retrospectively analyzed clinical features of respiratory virus infections of alloSCT recipients in our institute. Methods: Oropharyngeal swab, sputum, or bronchoalveolar lavage fl uid were sampled from alloSCT recipients with respiratory symptoms. Respiratory viruses were detected by viral culture or RT-PCR. Respiratory virus infection was diagnosed by both the presence of respiratory symptoms and detection of respiratory virus. Upper (URTI) and lower respiratory tract infection (LRTI) were diagnosed by radiologic fi ndings. Results: We analyzed 530 recipients undergone alloSCT in our institute from January 2006 to December 2010. Sixty-one patients were diagnosed as respiratory virus infection. The viruses detected included respiratory syncytial virus (RSV, 22 cases), parainfl uenza virus type 3 (PIV3, 37 cases), and adenovirus (ADV, 4 cases). In one patient, RSV and PIV3 were detected in separated periods. LRTI by RSV, PIV3, and ADV developed in 13 (59%), 10 (27%), 3 (75%) cases, and their mortality rates were 61%, 50%, 66.7%, respectively. The coinfection of other pathogens (Pseudomonas aeruginosa, Stenotrophomonas maltophilia, Aspergillus spp., et al) was more highly associated with the mortality of RSV LRTI than those of PIV3 or ADV LRTIs. Risk factors for death by respiratory virus infection were low lymphocyte counts (Lymphocyte
2011

abstract No: 

P766

Full conference title: 

Annual Meeting of the EBMT, 37th
    • EBMT 37th (2011)