Pulmonary aspergillosis in the context of AML

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A 50 year old Caucasian male with a history of acute myeloid leukaemia (AML), diagnosed on February 2000, developed probable pulmonary aspergillosis. Following two cycles of chemotherapy the patient achieved remission on early April 2000. He additionally received steroids for 9 days while on therapy. He then developed fever and neutropenia, and he was treated with broad spectrum antibiotics. His invasive Aspergillosis was diagnosed based on chest CT (multiple bilateral nodules/infiltrates) and repeatedly positive sputum cultures for Aspergillus flavus. After two months the patient appeared refractory (progression of disease) to AmBisome treatment, he was then treated with caspofungin for a prolonged period of 93 days, because of re-development of neutropenia and fever after initial resolution, until he had a significant improvement of CT-scan findings, complete remission of signs and symptoms for several days prior to discontinuation of caspofungin.


  • Aspergillus flavus