Prospective aspergillus galactomannan detection in allogeneic hematopoietic cell transplantation

M Rovira, E Carreras, F Fern;indez-Avii6s, J Mensa, M Ortega, M Rafel.


Poor prognosis of invasive aspergillosis (IA) is in part attributable to the absence of sensitive and specific non-invasive diagnostic tests. Since January 1999 through January 200 1, we prospectively investigate the usefulness of Aspergillus galactomannan antigen (AGA) by ELISA to evaluate patients undergoing allogeneic hematopoietic cell transplantation (alloHCT). Serum samples were collected from admission until discharge or death. Outpatients under immunosuppressive therapy were also monitored. Proven, probable and possible IA were defined according the EORTC-MSG criteria. During this period 74 patients underwent alloHCT Of these, 8 patients (10%) had clinical suspicion of IA (5 probable and 3 possible). All these patients died, 6 in relation with IA. in 3 with probable IA an autopsy was performed confirming the diagnosis. Detection of AGA was positive in 7 out of 8 patients with clinical suspicion of IA and negative in the remaining 66 alloHCT (p

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Trends in Invasive fungal Infections 6, 2001
    • TIFI 6th