Prognostic impact of haematological and non-haematological malignancies on mortality of hospitalised pneumonia: a Danish population-based cohort study

M. Nørgaard, A. Riis, R.W. Thomsen, H.C. Schønheyder, H.T. Sørensen

Author address: 

Aalborg, Aarhus, DK

Abstract: 

Objectives: To examine mortality of hospitalised pneumonia within 90 days of follow-up among patients with haematological and non-haematological malignancies. Methods: We conducted a population-based cohort study in three Danish counties (population 1.4 million). Through the regional hospital discharge registries we identified all adults (≥ 15 years) with a firsttime hospital discharge diagnosis of pneumonia between 1999 and 2003 (n = 41 793). We furthermore obtained information on previous discharge diagnoses including haematological and non-haematological malignancies. The patients were followed for mortality through the Danish Civil Registration System. We estimated mortality ratio (MRR) using Cox regression analysis with adjustment for calendar year, age, gender, and co-morbidity. Results: Among 41 793 patients hospitalised with pneumonia 423 (1%) had a haematological malignancy and 3138 (8%) had a non-haematological malignancy diagnosed prior to hospitalisation with pneumonia. Another 87 patients had both a haematological and a non-haematological malignancy. Cumulative 90-day mortality following pneumonia in patients without any malignancy was 21% vs. 31% in patients with haematological malignancies and 34% in patients with non-haematological malignancies. Compared with patients without any malignancy the adjusted 90-day MRR was 1.6 (95% CI 1.4-2.0) for patients with haematological malignancies and 1.5 (95% CI 1.4-1.6) for patients with non-haematological malignancies. Conclusion: Among patients with a first-time hospitalisation with pneumonia both haematological and non-haematological malignancies are associated with substantially increased 90-day mortality.
2006

abstract No: 

P1043

Full conference title: 

16th European Congress of Clinical Microbiology and Infectious Diseases
    • ECCMID 16th (2006)