Prevalence, Specie Distribution and Antifungal Susceptibility Profile Among Candida spp. Isolates from Human Immunodeficiency Virus (HIV-1) Seropositive and Pregnant Women

Rodrigo Mendes, Maria Mazzarolo, Leila Almeida, Daniel Archimedes, Priscilla Lindsey, Adauto Castelo, Arnaldo Colombo


Background: Mucosal candidiasis, including oropharyngeal, esophageal and vaginal candidiasis, are the most common cause of opportunistic mucosal infections in human immunodeficiency virus (HIV) positive women. In addition, pregnancy is also believed to predispose to vaginal candidiasis. This study was conducted to determine the prevalence, specie distribution and antifungal susceptibility profile (ASP) among Candida spp. isolates from HIV seropositive and pregnant human. The relationship between candidal vaginal colonization (CVC) and immunologic status was also evaluated. Methods: A total of 164 women were followed in the present study during prenatal care conducted between 1999 to 2001. Each woman had blood collected for enumeration of CD4 cells followed by vaginal sampling during pelvic examination. Yeast isolates were identified by classical methods and the ASP was performed according to the NCCLS microbroth assay. Ficher´s exact test and qui2 were used to determine the relationship between CVC and immunologic status. Finding were considered statistically significant at the p

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American Society for Microbiology General Meeting
    • ASM 102nd (2002)