Prevalence and risk factors for Aspergillus spp. colonization in patients with acute exacerbations of chronic obstructive pulmonary disease (AECOPD): The multi-center FUNGI-COPD study

Arturo Huerta, Nestor Soler, Raquel Martí­nez, Paula Losada, Virginia Almadana, Nuria Mir, Rebeca Domingo, Antoni Torres.

Author address: 

1Servicio de Pneumologia, Hospital Clinic de Barcelona, Spain 2Servicio de Pneumologia, Hospital La Fe, Valencia, Spain 3Servicio de Pneumologia, Hospital Cruces, Bilbao, Spain 4Servicio de Pneumologia, Hospital Virgen de la Macarena, Sevilla, Spain

Abstract: 

The role of non-usual organisms such as Aspergillus spp. in AECOPD have not been well established. AIM: 1) To analyze the prevalence of Aspergillus spp. in COPD patients requiring hospitalization due to an exacerbation and 2) To determine the risk factors for colonization in this population. METHODS: Patients with COPD and criteria for hospitalization in four centers across Spain were prospectively collected from February 2008 to April 2009. All patients received standard treatment for their exacerbation. Sputum and blood samples were collected at admission and day-3. A follow-up visit was performed at 1, 6 and 12 months after exacerbation. All re-hospitalizations were recorded. RESULTS: A total of 307 patients (age 71.5, SD 8.67) with AECOPD were included. Valid sputum sample was done in 77%. The overall prevalence for Aspergillus spp. in our population was 7.1%. Univariate analysis showed association between Aspergillus spp. and AECOPD requiring hopitalization in the last year (p
2010

abstract No: 

P4676

Full conference title: 

20th European Respiratory Society conference
    • ERS 20th (2010)