Prevalence Of Allergic Diseases and/Or Allergic Sensitization In Children and Adolescents With Type 1 Diabetes Mellitus

Dr. Hadley Vila-Nova, MD, Prof. Angela Spinola-Castro, MD, PhD, Dr. Fabíola E. Garcia, MD, Prof. Dirceu Sole, MD, PhD



The prevalence of atopic diseases in children with type 1 diabetes mellitus (DM1) has been reported as lower. The aim of this study was to evaluate the prevalence of allergic diseases and allergic sensitization in Brazilian children and adolescents with DM1.



96 DM1 patients (aged 4-18 years, 45 boys) followed for at least one year, were evaluated for allergic disease through a detailed allergologic anamnesis and skin prick tests (SPT) to inhalant allergens (D.pteronyssinus, D.farinae, B.tropicalis, B.germanica, P.americana, dog epithelium, cat epithelium, mix fungi), foods (cow’s milk, egg-white, yolk, soy, wheat, corn), positive (histamine 1mg/mL) and negative (saline) controls. Wheal with a mean diameter of induration equal or greater than 3mm identified a positive SPT.



The prevalence of rhinitis, asthma and atopic eczema (isolated or associated) were 68.0%, 59.1% and 44.4%, respectively. 20.6% of the patients had no allergic disease. Half of the patients were diagnosed with DM1 for at least four years and there was no relationship between the period of DM1 and the presence of allergic disease, as well as of the gender. 48.0% patients were sensitized with predominance of D.pteronyssinus, B.topicalisand D.farinae. The frequency of positive SPT was significantly higher among patients with a history of allergic disease (OR=6.98, 95%CI:2.60-18.74, p<0.001).



The prevalence of allergic diseases and sensitization in patients with DM1 was higher than usually expected and deserves further investigation to identify possible causes for these findings and to evaluate their importance and influence on the metabolic control.

abstract No: 

    • AAAAI 2014 (70th)