Pharmacodynamics of Itraconazole in a Methylprednisolone & Cyclosporin A-Immunosuppressed Rabbit Model of Invasive Pulmonary Aspergillosis.

T.WALSH, J.BERENGUER, M.ALLENDE, J.LEE, K.GARRETT, S.BATTAGLIA, N.ALI, M.RINALDI, AND P.PIZZO.

Abstract: 

Itraconazole (IT) and amphotericin B (AmB) were studied in a model of chronic invasive pulmonary aspergillosis in rabbits immunosuppressed with methylprednisolone (5 mg/kg/d on days 1-3, then 2 mg/kg/d) and cyclosporin A (CsA) (10 mg/kg/d). NZW rabbits received an endotracheal inoculation of /1.8 x 108 conidia of A. fumigatus and three treatment groups were studied: AmB 1 mg/kg/d IV (n=12), IT 40 mg/kg/d PO (n=14), and untreated controls (n=9). Both IT and AmB had antifungal activity in reducing tissue burden [CFU/g], pulmonary lesion score, lung weight , and organisms in bronchoalveolar Iavage (BAL) fluid [CFU/ml] in comparison to that of untreated controls (p50.01). IT and AmB were equivalent in reducing pulmonary lesions and lung weight. However, AmB was more active in reducing the tissue burden of A. fumigatus (AmB, log [CFU/g]=0.06 t 0.04 vs. IT, log [CFU/g]=1.52 t 0.17 (p
1993

abstract No: 

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Full conference title: 

ICAAC 33rd, 1993
    • ICAAC 33rd