Pharmacodynamics of BAL4815, a New Azole Antifungal in a Mouse Model of Systemic Infection

Debbie T.A. te Dorsthorst1,2,3, Paul E. Verweij2,3, Jacques F.G.M. Meis1, and Johan W. Mouton1

Author address: 

1Canisius Wilhelmina Hospital, Nijmegen, The Netherlands, 2University Medical Center St Radboud, Nijmegen, The Netherlands, 3Nijmegen University Center for Infectious Diseases, Nijmegen, the Netherlands.


BAL4815 is a new antifungal agent, which belongs to the azoles. BAL4815 is administered as the water-soluble pro-drug BAL8557 (figure 1). In vitro, BAL4815 showed broad-spectrum antifungal activity against Candida spp. (including fluconazoleresistant C. albicans), Cryptococcus spp., Aspergillus spp., Absidia spp., Rhizopus spp., Rhizomucor spp., Histoplasma capsulatum, and Blastomyces dermatitidis [2].

    • ICAAC 44th