Phaeoacremonium aleophilum skin and soft tissue infection in a renal trannsplant patient.

Harigopal P, Ciancio G, Dowdy L

Author address: 

University of Miami School of Medicine, Miami USA


Unusual fungal infections are being encountered with increased frequency in the immunocompromised host. Phaeoacremonium aleophilum is a dark pigmented fungus known to grow on stems and roots of grape vines (Vitis vinifera.) The first case of soft tissue infection caused by this fungus was reported in an immunocompetetent host in Brazil .1 He was successfully treated with itraconazole.We report the second case of soft tissue infection with phaeaocremonium aleophilum and the first in a renal transplant patient. A 61 year old black male with a history of diabetes mellitus underwent cadaveric kidney transplantation in October 2003. He presented in March of 2004 with a four day history of swelling of his right middle finger. It was associated with severe pain and the swelling gradually increased to involve his right hand and extended upwards into his forearm. Blood cultures were negative. Phaeaocremonium aleophilum was isolated from wound cultures. He was treated with Amphotericin B lipid complex followed by Voriconazole for 6 weeks with complete resolution of his symptoms. Paheoacremonium sp is a rare cause of human infection .Accurate diagnosis requires tissue cultures so appropriate treatment is not delayed. This is the first case of Phaeoacremoniumaleophilum infection in the literature in a solid organ transplanted patient. References. 1. Josep Guarro ET al 2003. Two cases of Subcutaneous Infections Due to Phaeoacremonium spp. J Clin Microbiol.2003 March; 41(3):1332-1336.

abstract No: 


Full conference title: 

15th Annual Focus on Fungal Infections
    • FFI 15th (2005)