Penicillium sp. infection after chemotherapy for leukemia and bone marrow transplantation. Report of three cases.

E Sanchez-Cortés, J Gaytan-Martinez, E Mateos-Garcí­a, J Vela-Ojeda, F Tripp-Villanueva, MI Rojas-Castañeda, S Rios-Martinez, JL Fuentes-Allende, J Gonzallez-LLaven


Candida and Aspergillus are the most common mycotic infections in patients (pts) with acute leukemia and BMT, other less common pathogens include Histoplasmosis, Cryptococcosis and Penicillium. We report here the first 3 Mexican cases of Penicillium sp infection after BMT and chemotherapy induced neutropenia.Between June 1996 and June 1997 we have studied 3 pts with Penicillium sp infection isolated from bronchoalveolar lavage or bone marrow culture. 2 pts were female and one male, mean age of 36 years. two pts. had Penicillium sp pneumonia after BMT both with graft versus host disease Predominant clinical symptoms were: fever, dyspnea, tachypnea and productive cough. Third patient has severe nuetropenia after chemotherapy for acute myeloid leukemia Penicillium sp was isolated from bone marrow culture. All pts. were treated with amphotericin B Two of them died and the one who survive was treated with amphotericin B plus itraconazole up to 6 months.Penicillium sp must be considered a cause of mycotic infection (pneumonia or septicemia) in immunodeficient pts.

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39th meeting of the American Society for Haemotology
    • ASH 39th (1998)