Penicillic acid

Toxin: 

y

Trivial name: 

Penicillic acid (6CI); 3-​Methoxy-​5-​methyl-​4-​oxo-​2,​5-​hexadienoic acid; NSC 402844; γ-​keto-​β-​Methoxy-​δ-​methylene-​Δα-​hexenoic acid

Systematic name: 

2,5-Hexadienoic acid, 3-methoxy-5-methyl-4-oxo-

Molecular formulae: 

C8H10O4

Molecular weight: 

170.16

Chem abstract number: 

90-65-3

Literature reference: 

Penicillic acid from Aspergillus ochraceus, Penicillium thomii, and Penicillium suavolens, Karow, E. O.; Woodruff, H. B.; Foster, J. W. Archives of Biochemistry (1944), 5, 279-82. The nature of some antibiotics from Aspergillus. Gill-Carey, D. British Journal of Experimental Pathology (1949), 30, 119-23. Antibiotics from Aspergillus melleus. Burton, H. S. Nature (London, United Kingdom) (1950), 165, 274-5. Chemical and cytotoxicity survey on the metabolites of toxic fungi. Umeda, Makoto; Yamashita, Tatsuo; Saito, Mamoru; Sekita, Setsuko; Takahashi, Chikako; Yoshihira,...

Toxicity: 

mouse LD50 intraperitoneal 90mg/kg (90mg/kg) Toxicology and Applied Pharmacology. Vol. 52, Pg. 1, 1980. Link to PubMed mouse LD50 intravenous 250mg/kg (250mg/kg) Journal of Pharmacology and Experimental Therapeutics. Vol. 88, Pg. 119, 1946. mouse LD50 oral 600mg/kg (600mg/kg) Journal of Pharmacology and Experimental Therapeutics. Vol. 88, Pg. 119, 1946. mouse LD50 subcutaneous 100mg/kg (100mg/kg) "Merck Index; an Encyclopedia of Chemicals, Drugs, and Biologicals", 11th ed., Rahway, NJ 07065, Merck & Co., Inc. 1989Vol. 11, Pg. 1122, 1989. mouse LDLo unreported 280mg/kg (280mg/kg) British Journal of Cancer. Vol. 15, Pg. 85, 1961. Link to PubMed rat LD50 intraperitoneal 90mg/kg (90mg/kg) LIVER: EFFECTS: OTHER CHANGES Journal of Toxicology and Environmental Health. Vol. 7, Pg. 169, 1981. Link to PubMed

Structure image: 

Aspergillus Species known to produce this metabolite: 

3d image file .s3d (get free desktop viewer at http://www.acdlabs.com/resources/freeware/): 

jmol file (.mol) requires Java to run (http://www.java.com/en/download/help/enable_panel.xml): 


Date uploaded: 

2005-12-14 00:00:00