Introduction: There is compelling evidence that a link exists between the upper and the lower airway and that rhinitis has a remarkable impact on asthma. In a large population-based sample, major chronic conditions occur more frequently in people with asthma. Design, setting and participation: We aimed to quantify baseline rates of co-morbidities in asthma and to compare the risks to the general population. The study was conducted among patients with clinical diagnosis of asthma who came to National Asthma, Allergy & Bronchitis Institute, a nodal airways disease treatment and research institute in Kolkata. We compared incident patients with asthma (n = 501) physician diagnosed in 2008-2009 with cohorts from previous studies. Rates were calculated and relative risks (RRs) were estimated for co-morbidities in major organ systems and selected medical events of a priori interest. Results: It was seen that allergic rhinitis(90%, RR 20) and Gastro Oesophageal Reflux Disease (44.6%, RR 8) were the commonest co-morbid conditions among patients in Eastern India with a high relative risk. The risk of IHD was also greater (RR 8) Interestingly the risk of atopic dermatitis or eczema was no higher than the general population. Other respiratory conditions like Allergic Bronchopulmonary Aspergillosis (1.6%), Obstructive Sleep Apnoea(1.6%), Vocal Cord Dysfunction (1.8%), TB(7.6%), and pneumonia(16%) also did not have an increased relative risk. Conclusion: Asthma is associated with many co-morbidities and has not been systematically reviewed before in an Indian perspective. The incidence of allergic rhinitis and gastrointestinal reflux disease is higher than it has been reported from other parts of the world.
Full conference title:
20th European Respiratory Society conference
- ERS 20th (2010)