Paediatric Fungal infections

This section summarises published information regarding the concepts in managing invasive fungal infections in children, with specific reference to Aspergillus.

Broadly there are two sections comprising diagnosis and treatment regimes. The data here are sourced and summarised from a series of publications in Clinical Microbiology Infect. 16(9), 1319-53, 2010 by Groll et alWalsh et alDornbusch et al& all these references are more comprehensive than the data compiled here and we recommend referral to the original publications for further detail. 
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Children and in particular neonates and young infants, are a unique patient population, particularly with respect to fungal infections. 
Invasive fungal infections are dificult to diagnose - but response to treatment and outcome is dependent on a prompt initial diagnosis and the initiation of treatment.

Epidemiology and Clinical Trials

The epidemiology, presentation and pre-disposing conditions show significant differences in paediatric versus adult patients. 
The use of antifungal agents in this patient group requires an understanding of pharmacodynamics and safety issues - which accumulating evidence suggests can not always be empirically derived from data collected on usage in adult groups.

Many antifungal clinical trials have previously excluded paediatric groups so there is a lack of trials of large cohorts- but there is data in the literature for smaller cohorts of paediatric patients- for various antifungal treatments.
New antifungals are continually going into trials - however the need for evaluation in paediatric patients is great.

This website specialises in Aspergillus infections - but the lack of paediatric data has meant that we have included data for other types of fungal infections - where it may be useful. 

Computed content type (Paediatrics): 


Paediatric articles

Displaying 1 - 10 of 158
Author year
Infectious and non-infectious complications in primary immunodeficiency disorders: an autopsy study from North India Kirti Gupta, Amit Rawat, Parimal Agrawal, Ankur Jindal, Ritambhra Nada, Biman Saikia, Koon Wing Chan, Yu Lung Lau, Ranjana Walker Minz, Surjit Singh. 2018
Use of Galactomannan Antigen and Aspergillus DNA Real-time Polymerase Chain Reaction as Routine Methods for Invasive Aspergillosis in Immunosuppressed Children in Greece. Vrioni G, Theodoridou K, Tsiamis C, Mavrouli M, Kapsimali V, Rigopoulos D, Tsakris A. 2018
A review of 42 asthmatic children with allergic bronchopulmonary aspergillosis Shah A, Kunal S 2017
Risk factors for early invasive fungal infections in pediatric liver transplant recipients Pasternak Y, Rubin S, Bilavsky E, Mozer-Glassberg Y, Levy I, Nahum E, Rom E, Gurevich M, Ben-Zvi H, Ashkenazi-Hoffnung L 2018
Epidemiology of Invasive Fungal Disease in Children Pana ZD, Roilides E, Warris A, Groll AH, Zaoutis T 2017
Recognition and Clinical Presentation of Invasive Fungal Disease in Neonates and Children King J, Pana ZD, Lehrnbecher T, Steinbach WJ, Warris A 2017
Itraconazole Dosing and Drug Monitoring at a Tertiary Children's Hospital Leong YH1, Boast A1, Cranswick N, Curtis N, Gwee A 2018
Micafungin in invasive fungal infections in children with acute leukemia or undergoing stem cell transplantation. Styczynski J, Czyzewski K, Wysocki M, Zajac-Spychala O, Wachowiak J, Ociepa T, Urasinski T, Gryniewicz-Kwiatkowska O, Kolodziejczyk-Gietka A, Dembowska-Baginska B, Perek D, Salamonowicz M, Hutnik L, Matysiak M, Siewiera K, Frackiewicz J, Kalwak K, Badowska W, Malas Z7, Gozdzik J, Urbanek-Dadela A, Karolczyk G, Stolpa W, Sobol G, Gamrot Z, Woszczyk M, Gil L 2016
Voriconazole Antifungal Prophylaxis in Children With Malignancies: A Nationwide Study Pana ZD, Kourti M, Vikelouda K, Vlahou A, Katzilakis N, Papageorgiou M, Doganis D, Petrikkos L, Paisiou A, Koliouskas D, Kattamis A, Stiakaki E, Chatzistilianou M, Vasilatou-Kosmidis H, Polychronopoulou S, Grafakos S, Roilides E 2018
Clinical features of children with acute lymphoblastic leukemia complicated by pulmonary infection after chemotherapy [Clinical features of children with acute lymphoblastic leukemia complicated by pulmonary infection after chemotherapy]. Zhang PF, et al. Zhongguo Dang Dai Er Ke Za Zhi. 2017