Paediatric Fungal infections

This section summarises published information regarding the concepts in managing invasive fungal infections in children, with specific reference to Aspergillus.

Broadly there are two sections comprising diagnosis and treatment regimes. The data here are sourced and summarised from a series of publications in Clinical Microbiology Infect. 16(9), 1319-53, 2010 by Groll et alWalsh et alDornbusch et al& all these references are more comprehensive than the data compiled here and we recommend referral to the original publications for further detail. 
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Children and in particular neonates and young infants, are a unique patient population, particularly with respect to fungal infections. 
Invasive fungal infections are dificult to diagnose - but response to treatment and outcome is dependent on a prompt initial diagnosis and the initiation of treatment.


Epidemiology and Clinical Trials

The epidemiology, presentation and pre-disposing conditions show significant differences in paediatric versus adult patients. 
The use of antifungal agents in this patient group requires an understanding of pharmacodynamics and safety issues - which accumulating evidence suggests can not always be empirically derived from data collected on usage in adult groups.


Many antifungal clinical trials have previously excluded paediatric groups so there is a lack of trials of large cohorts- but there is data in the literature for smaller cohorts of paediatric patients- for various antifungal treatments.
New antifungals are continually going into trials - however the need for evaluation in paediatric patients is great.


This website specialises in Aspergillus infections - but the lack of paediatric data has meant that we have included data for other types of fungal infections - where it may be useful. 

Computed content type (Paediatrics): 

Paediatrics

Paediatric articles

Displaying 1 - 10 of 148
Author year
Clinical and Pathological Correlation in Pediatric Invasive Pulmonary Aspergillosis. Anantasit N1,2, Nuntacharruksa N1, Incharoen P3, Preutthipan A1. 2018
Indoor fungal diversity in primary schools may differently influence allergic sensitization and asthma in children. Cavaleiro Rufo J, Madureira J, Paciência I, Aguiar L, Pereira C, Silva D, Padrão P, Moreira P, Delgado L, Annesi-Maesano I, Oliveira Fernandes E, Teixeira JP, Moreira A 2017
Efficacy and safety of caspofungin in children: systematic review and meta-analysis. Rosanova MT, Bes D, Serrano Aguilar P, Cuellar Pompa L, Sberna N, Lede R 2016
Role of Molecular Biomarkers in the Diagnosis of Invasive Fungal Diseases in Children Huppler AR, Fisher BT, Lehrnbecher T, Walsh TJ, Steinbach WJ 2017
Voriconazole Antifungal Prophylaxis in Children With Malignancies: A Nationwide Study. Pana ZD, Kourti M, Vikelouda K, Vlahou A, Katzilakis N, Papageorgiou M, Doganis D, Petrikkos L, Paisiou A, Koliouskas D, Kattamis A, Stiakaki E, Chatzistilianou M, Vasilatou-Kosmidis H, Polychronopoulou S, Grafakos S, Roilides E. 2018
Efficacy and safety of itraconazole use in infants Chen S, Sun KY, Feng XW, Ran X, Lama J, Ran YP 2016
Toxicity of Vincristine Combined With Posaconazole in Children With Acute Lymphoblastic Leukemia Pekpak E, İleri T, İnce E, Ertem M, Uysal Z 2017
A clinical analysis of micafungin treatment of pulmonary invasive fungal infection in pediatric patients with acute leukemia or post hematopoietic stem cells transplantation Huang K, Qiu KY, Deng LL, Fang JP, Li Y, Guo HX, Zhou DH. 2017
Fungal and Parasitic CNS Infections Singhi P, Saini AG 2017
Antifungal Drugs in Newborns and Children Puia-Dumitrescu M, Smith PB 2017

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