Osteoarticular Mycoses - Comparative Analysis of the Epidemiology, Pathogenesis, Clinical, Diagnostic, and Therapeutic Characteristics of 1011 Cases

M. Gamaletsou, B. Rammaert, M. Bueno, B. Brause, D. Denning, M. Henry, D. M. Kontoyiannis, A. Miller, R. Petraitiene, V. Petraitis, E. Roilides, N. V. Sipsas, S. Taj-Aldeen, V. Zeller, O. Lortholary, T. Walsh

Author address: 

Intl. Consortium for Study of Osteoarticular Mycoses, New York, NY


Background: Osteoarticular mycoses (OM) are chronic debilitating infections that require extended courses of antifungal therapy and may warrant expert surgical intervention. To our knowledge, there is no systematic analysis of the different forms of osteoarticular mycoses. Methods: Using a database of 1011 cases fulfilling prespecified criteria, we studied the comparative epidemiology, pathogenesis, clinical manifestations, inflammatory biomarkers, treatment and outcome of six major groups of OM: Candida osteomyelitis (CO), Aspergillus osteomyelitis (AO), Candida arthritis (CA), Aspergillus arthritis (AA), dimorphic fungal osteomyelitis (DFO), and non-Aspergillus mould osteomyelitis (NAMO).Results: The age range extended from neonates to older adults most widely in CO and CA. For all OM, M:F ratio= 2.1. CO and CA, were associated with significantly greater events of hematogenous dissemination in 67% and 81%, respectively, than that of AO (45%) and than that of NAMO (39%) (P

abstract No: 


Full conference title: 

ASM Microbe 2016
    • ASM microbe 1st (2016)