Oral cavity mycosis in patients with malignancies under radiotherapy

Pytko-Polonczyk1, J.M., Macura2, A.B.

Author address: 

1 Dentistry, KRAKí“W, Poland 2Department Mycology, Chair of Microbiology, KRAKí“W, Poland


Introduction: Oral mycosis is a common complication of oral and/or central pharynx cancer under radiotherapy. Objective: The objective of the study was clinical and mycological evaluation of the oral cavity condition before and during radiotherapy. Materials & methods: Thirty persons aged 26 to 76 years were enrolled into the study (nine females and twenty one males). A clinical examination, concerning the condition of the teeth, periodontium and the mucous membrane, was performed three times: before and on the 2nd and 4th weeks of the radiotherapy. Buccal mucosa smears and oral washings were taken at each of the examinations. In the mycological assessment, the presence of certain fungal species was detected as well as semiquantitative evaluation of their abundance was performed. The latter was expressed as +, ++, +++, and ++++. Results: Out of the thirty persons under study, twenty eight were heavy smokers. Before the radiotherapy, fungi Candida were isolated from eight persons. Their abundance was either intermediate or mild (C. albicans in six patients while other Candida species in two of them). On the second week of radiotherapy, the Candida fungi were isolated from twenty persons. Their growth was abundant in eighteen of the cases and confluent in the remaining two (C. albicans was found in sixteen cases, and other Candida species in the remaining four). On the fourth week of radiotherapy, Candida fungi were isolated from twenty one patients (C. albicans in seventeen cases, and other Candida species in four of them). Confluent growth was seen in four cases, and abundant in the remaining ones. Conclusions: 1.The clinical condition of the oral cavity in the patients with malignancies is worsened during the radiotherapy, with the occurrence of erosions and ulcerations. 2.Simultaneously, increase the symptoms and signs of oral candidiasis, and the abundance of fungal flora. 3.C. albicans outnumbers other Candida species in the patients with candidiasis.

abstract No: 


Full conference title: 

3rd Trends in Medical Mycology
    • TIMM 3rd (2011)