Ophiobolin A

Toxin: 

n

Trivial name: 

Cochliobolin A (7CI); Ophiobola-​7,​19-​dien-​25-​al, 14,​18-​epoxy-​3-​hydroxy-​5-​oxo-​, (18R)​- (8CI); Ophiobolin (6CI); Spiro[dicyclopenta[a​,​d]​cyclooctene-​3(2H)​,​2'(3'H)​-​furan]​-​6-​carboxaldehyde, 1,​3a,​4,​4',​5',​6a,​7,​8,​9,​9a,​10,​10a-​dodecahydro-​9-​hydroxy-​3',​9,​10a-​trimethyl-​5'-​(2-​methyl-​1-​propenyl)​-​7-​oxo-​, (2'S,​3'S,​3aR,​5'R,​6aS,​9R,​9aS,​10aR)​- (9CI); (+)​-​Ophiobolin A; Cochliobolin; NSC 114340; Ophiobolin A; Spiro[dicyclopenta[a​,​d]​cyclooctene-​3(2H)​,​2'(3'H)​-​furan]​-​6-​carboxaldehyde, 1,​3a,​4,​4',​5',​6a,​7,​8,​9,​9a,​10,​10a-​dodecahydro-​9-​hydroxy-​3',​9,​10a-​trimethyl-​5'-​(2-​methyl-​1-​propenyl)​-​7-​oxo-​, [3S-​[3α(3'R*,​5'S*)​,​3aα,​6aβ,​9α,​9aβ,​10aβ]​]​-

Systematic name: 

Spiro[dicyclopenta[a,​d]​cyclooctene-​3(2H)​,​2'(3'H)​-​furan]​-​6-​carboxaldehyde, 1,​3a,​4,​4',​5',​6a,​7,​8,​9,​9a,​10,​10a-​dodecahydro-​9-​hydroxy-​3',​9,​10a-​trimethyl-​5'-​(2-​methyl-​1-​propen-​1-​yl)​-​7-​oxo-​, (2'S,​3'S,​3aR,​5'R,​6aS,​9R,​9aS,​10aR)​-

Molecular formulae: 

C25H36O4

Molecular weight: 

400.55

Chem abstract number: 

4611-05-6

Literature reference: 

Ophiobolin type di-​sesquiterpene compounds, preparation and application thereof. Zhu, Weiming; Lu, Zhenyu; Hong, Kui; Miao, Chengdu. Faming Zhuanli Shenqing (2009), CN 101591314 A 20091202. Morphological and molecular identification of ophiobolins producing strain F02Z2172. Li, Yeying; Shi, Ying; Lu, Xinhua; Cui, Xiaolan; Ma, Ying; Zhao, Ying; Liu, Jing; Zhang, Hua. Weishengwuxue Tongbao (2010), 37(8), 1205-1210. New taxa in Aspergillus section Usti. R.A. Samson1*, J. Varga1,2, M. Meijer1 and J.C. Frisvad3. Studies in Mycology 69: 81–97. 2011

Structure image: 

Aspergillus Species known to produce this metabolite: 

Date uploaded: 

2011-10-05 15:13:34