Ochratoxin A

Toxin:

y

Trivial name:

Alanine, N-[(5-chloro-8-hydroxy-3-methyl-1-oxo-7-isochromanyl)carbonyl]-3-phenyl-, (-)- (8CI); L-Phenylalanine, N-[(5-chloro-3,4-dihydro-8-hydroxy-3-methyl-1-oxo-1H-2-benzopyran-7-yl)carbonyl]-, (R)-; Ochratoxin A (7CI); (R)-N-[(5-Chloro-3,4-dihydro-8-hydroxy-3-methyl-1-oxo-1H-benzo[c]pyran-7-yl)carbonyl]-3-phenylalanine; 3R,14S-Ochratoxin A; NSC 201422; NSC 221991; Phe-OTA; Phenylalanine-ochratoxin A

Systematic name:

L-Phenylalanine, N-[[(3R)-5-chloro-3,4-dihydro-8-hydroxy-3-methyl-1-oxo-1H-2-benzopyran-7-yl]carbonyl]-

Molecular formulae:

C20H18ClNO6

Molecular weight:

403.81

Chem abstract number:

303-47-9

References (URL):

Pubchem

Ochratoxin A, a toxic metabolite produced by Aspergillus ochraceus.

A review on ochratoxin A occurrence and effects of processing of cereal and cereal derived food products

Literature reference:

Ochratoxin A, a toxic metabolite produced by Aspergillus ochraceus. van der Merwe, K. J.; Steyn, P. S.; Fourie, L.; Scott, D. B.; Theron, J. J. Nature (London, United Kingdom) (1965), 205(4976), 1112-13 A review on ochratoxin A occurrence and effects of processing of cereal and cereal derived food products. S.C. Duarte, , A. Pena, C.M. Lino. Food Microbiology Volume 27, Issue 2, April 2010, Pages 187–198.

Chemical type:

Isocoumarin

Toxicity:

Potent nephrotoxin implicated in porcine nephropathy. Acute oral LD50 in the male rat 30.3 mg/kg body-weight and in the female rat 21.4 mg/kg body-weight. Recent assessments of toxicity suggest that this compound may be carcinogenic and genotoxic. chicken LD50 oral 3300ug/kg (3.3mg/kg)