Not Just for Beta(B)-1,3-Glucan(G) Any More: Caspofungin (C) Inhibition of B-1,6-G Demonstrated at Inhibitory C Concentrations (Conc.).

D. A. STEVENS1,2, H. HORIUCHI 3, M. TSUIZAKI 3, M. MARTINEZ 1, A. TONG 1;

Author address: 

1California Inst. for Med. Res. and Santa Clara Valley Med. Ctr., San Jose, CA, 2Stanford Univ., Stanford, CA, 3Univ. of Tokyo, Tokyo, Japan.

Abstract: 

Background: We have previously suggested that, in addition to the well-known C mechanism of action in inhibiting Candida cell wall synthesis, inhibition of B-1,3-G synthesis, additional fungal inhibition could occur from inhibition of B-1,6-G (AAC 50:3160). However, this emanated from studies of supra-MIC paradoxical growth, cells escaping high C conc. by switching much cell wall content to chitin. The present studies of B-1,6-G inhibition were performed at the more relevant
2007

abstract No: 

M-1813

Full conference title: 

47th Interscience Conference on Antimicrobial agents and Chemotherapy
    • ICAAC 47th