A New Family of Cationic Poly-Heterocyclic Compounds is Fungicidal against Pathogenic Yeasts and Molds: Demonstration of Efficacy In Vivo.

M.D. VELLIGAN1, A. KONGPACHITH1, D. STEVENS2, E. MICHELOTTI1, J. BOTYANSZKI1, K. CLEMONS2, L. LOU1, M. VIGIL1

Author address: 

1 Genelabs Technologies, Inc., Redwood City, CA, 2 Div. Infectious Disease, Sta. Clara. Vly. Med Ctr., Div. Infectious Diseases and Geo. Med., Stanford U., Stanford, CA; Cal. Institute for Med. Res., San Jose, CA

Abstract: 

We have synthesized a new class of antifungal compounds where an initial lead (GL047296) is fungicidal against a variety of common pathogenic yeasts and molds. These compounds bind reversibly to dsDNA within the minor groove. Here we report that GL663142, a derivative with improved metabolic stability, is active against Candida sp., some Aspergillus sp. and C. neoformans subtypes. It is fungicidal against Fusarium, certain endemic dimorphic species, and dermatophytes with most MIC and MFC values in
2002

abstract No: 

F-833

Full conference title: 

42nd Interscience Conference on Antimicrobial Agents and Chemotherapy
    • ICAAC 42nd