Mucosal candidiasis in transgenic mice expressing human immunodeficiency virus type 1

de Repentigny, L.;Aumont, F.;Ripeau, J. S.;Fiorillo, M.;Kay, D. G.;Hanna, Z.;Jolicoeur, P.

Author address: 

de Repentigny, L, Hop St Justine, Dept Microbiol & Immunol, 3175 Cote Ste Catherine, Montreal, PQ H3T 1C5, Canada

Abstract: 

The availability of CD4C/HIVMutA transgenic (Tg) mice expressing human immunodeficiency virus type 1 in immune cells and developing an AIDS-like disease has provided the opportunity to devise a model of mucosal candidiasis that closely mimics the clinical and pathologic features of candidal infection in human AIDS. After intraoral infection with Candida albicans, oral burdens were strikingly elevated in the Tg mice, compared with non-Tg littermates (P
2000

abstract No: 

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Full conference title: 

100th Annual Meeting of the American-Society-for-Microbiology
    • ASM 100th (2000)