Mucormycosis is a rare and invasive fungal infection which is frequently lethal. It affects commonly on immunocompromised patients, especially diabetics. The rhinocerebral form is the most frequent complication, but other localizations may occur. Objective: The aim of this study is to analyse demographic characteristics, clinical presentation, radiological findings, management and outcome of mucormycosis. Methods: We conducted a retrospective study of patients who developed a mucormycosis between January 1988 and December 2004 and admitted in the department of infectious diseases of Rabta hospital in Tunis. Diagnosis of mucormycosis was confirmed by mycological and/or histological findings. Results: 4 patients with mucormycosis were included in the study, 3 male and one female. The mean age is 53 years. All patients were diabetics, three of them had diabetic ketoacidosis at the time of diagnosis. The sites of infection were: sinonasal (2 cases), rhinocerebral infection (2 cases). One patient with rhinocerebral involvement had carotid artery thrombosis on RMI. The direct detection of fungus in tissues and samples were noted in all cases and Rhizopus oryzae grew in 3 cases. Our patients were treated with amphotericin B associated to surgical debridement of devitalized tissue in 3 cases. A fatal outcome was observed in two patients, whereas two patients are still alive with sequelae: facial paralysis and numbness (1 case) and facial necrosis (1 case). Conclusion: Mucormycosis remains a severe infection disease in diabetics patients. Early diagnosis and treatment are mandatory to improve survival and prevent brain dissemination.
Full conference title:
16th European Congress of Clinical Microbiology and Infectious Diseases
- ECCMID 16th (2006)