Monte Carlo Simulations of BAL8557, a New Watersoluble Azole with Antifungal Activity

Johan W. Mouton1, Anne Schmitt-Hoffmann2, Nieko C. Punt3

Author address: 

1Canisius-Wilhelmina Hospital, Nijmegen, The Netherlands; 2Basilea Pharmaceuticals, Basel, Switzerland; 3Medimatics, Maastricht, The Netherlands.

Abstract: 

Introduction:


BAL4815 is a new antifungal agent, which belongs to the azoles. BAL4815 is administered as the water-soluble prodrug BAL8557 (figure 1). In vitro, BAL4815 showed broadspectrum antifungal activity against Candida spp. (including fluconazole-resistant C. albicans ), Cryptococcus spp., and various filamentous fungi including fluconazole-resistant strains. Monte Carlo Simulations (MCS) is a technique that can be used to determine the Probability of Target Attainment (PTA) for pharmacodynamic indices (PDI). Results from a single dose pharmacokinetic study were used to determine PTAs and, based on levels of BAL4815 evaluate the potential use of BAL8557 to treat fungalb infections

    • ICAAC 44th