Molecular epidemiology of the global and temporal diversity of Candida albicans

McCullough, M. J.;Clemons, K. V.;Stevens, D. A.

Author address: 

Stevens, DA, Santa Clara Valley Med Ctr, Dept Med, Div Infect Dis, 751 S Bascom Ave, San Jose, CA 95128 USA


The epidemiology of Candida albicans has changed with the rise in immunocompromised patients and the pressures of antifungal treatment and prophylaxis, We assessed the genotype distribution of recently obtained, globally diverse isolates in comparison with isolates recovered in the United States and United Kingdom before 1985, in order to determine temporal and geographic differences, We used EcoRI digestion of cellular DNA to generate restriction fragment length polymorphisms, dividing the isolates into 4 groups. From 15 diverse geographic areas, 439 isolates obtained over 20 years were divided into 121 genotypes within groups A (289 isolates), B (85), C (56), and D (9), Differences in genotype distribution existed among the localities (P

abstract No: 


Full conference title: 

98th Meeting of the American-Society-for-Microbiology
    • ASM 98th (1998)