Microbiology from bronchoscopy in haematologic patients: comparison of stem cell recipients with nonrecipients

J.C. Kwon*, S.Y. Cho, S.H. Kim, S.H. Park, S.M. Choi, D.G. Lee, J.H. Choi, J.H. Yoo

Author address: 

(Seoul, KR)

Abstract: 

Objectives: We investigated microbiologic results of bronchoscopy (BRS) in haematologic patients with pneumonia and compared microbiology from haematopoietic stem cell recipients (HSCRs) with that from non-recipients (non-HSCRs). Methods: We retrospectively reviewed medical records of consecutive haematologic patients who experienced BRS from APR 2009 to AUG 2011 at the Catholic haematopoietic stem cell transplantation centre in Korea. Results: A total of 176 cases were identified. Mean age was 47.7 ± 15.4 years, and 122 patients (69.3%) were men. Underlying diseases were acute myelogenous leukemia (n = 65, 36.9%), acute lymphoblastic leukemia (n = 24, 13.6%), myelodysplastic syndrome (n = 26, 14.8%), etc. HSCR group accounted for 48.9% (n = 86), of which 87.2% (n = 75) were allo-HSCR. The number of culture-positive bacterial, fungal, and tuberculosis (TB) cases from brohchoalveolar lavage (BAL) were 44 (25.0%), 5 (2.8%), and 11 (6.3%), respectively. Acinetobacter baumannii (n = 10) was the most common bacterial isolate followed by methicillin-resistant Staphylococcus aureus (n = 9) and coagulase negative staphylococci (n = 6). Four Aspergillus, one Rhizopus and five non-TB mycobacterial cases were identified. Pneumocystis jiroveci polymerase chain reaction (PCR) was positive in 32 cases (18.2%). Multiplex PCR for respiratory viruses were performed in 147 cases, of which 21.1% (31/147) were positive. Respiratory synctivial virus (n = 11) was the most common virus followed by human rhinovirus (n = 10), parainfluenza virus (n = 9), influenza A (n = 4) and metapneumovirus (n = 1). In four cases, two different viruses were positive. One hundred thirty one cases were
2012

abstract No: 

P2120

Full conference title: 

22nd European Congress of Clinical Microbiology and Infectious Diseases
    • ECCMID 22nd (2012)