Markedly elevated serum lactate dehydrogenase levels are a clue to the diagnosis of disseminated histoplasmosis in patients with AIDS

Corcoran, G. R.;AlAbdely, H.;Flanders, C. D.;Geimer, J.;Patterson, T. F.

Author address: 

Patterson, TF, UNIV TEXAS,HLTH SCI CTR,DEPT MED,DIV INFECT DIS,7703 FLOYD CURL DR,SAN ANTONIO,TX 78284

Abstract: 

Disseminated histoplasmosis is a common late manifestation of AIDS, but the diagnosis may be unsuspected in some patients because the clinical presentation of histoplasmosis may mimic other opportunistic infections. High serum lactate dehydrogenase (LDH) levels have been associated with disseminated histoplasmosis. We therefore evaluated whether markedly increased LDH levels were useful for making a diagnosis of disseminated histoplasmosis by comparing admission LDH levels for 15 patients with culture-proven disseminated histoplasmosis with those for 30 patients dth advanced AIDS who were admitted to the hospital for evaluation of pulmonary infiltrates and fever. The mean admission LDH level in patients with disseminated histoplasmosis was 1,356 IU/L (range, 145- 5,410 IU) whereas it was 332 (range, 77-832 IU) in the patients with other pulmonary processes. Admission LDH levels were >600 IU in 11 (73%) of the 15 patients with disseminated histoplasmosis vs, 3 (10%) of controls (P <.001 we="" conclude="" that="" markedly="" elevated="" admission="" ldh="" levels="" may="" be="" a="" clinical="" clue="" to="" the="" diagnosis="" of="" disseminated="" histoplasmosis="" in="" patients="" with="" aids.="">
1995

abstract No: 

NULL

Full conference title: 

33rd Annual Meeting of the Infectious-Diseases-Society-of- America
    • IDSA 33rd