Cho BK, Kim JE, Park HJ, Lee JY

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We have a little information about long-term treatment results of onychomycosis depending upon the oral antifungal agents. This study was to evaluate the long-term follow up of onychomycosis after treating the 438 patients with one of the 3 drugs including itraconazole, terbinafine and fluconazole from January 1999 to August 2002 in St. Mary’s Hospital, Seoul. The proportion of onychomycosis among total nail disorders enlisted on the nail clinic chart during the same period was 69% (438/639). Itraconazole was prescribed according to the pulse therapy schedule (400 mg/day • 7 days • 3 pulse) and the other drugs were prescribed for 12 weeks (terbinafine, 250 mg/day) or once per week for 8 months (fluconazole, 150 mg/week). The percentage of the patients who had completely finished the course of the treatment are 61% (191/315) in itraconazole, 43% (30/69) in terbinafine and 21% (3/14) in fluconazole. Cure rates after 1year of treatment were 34% (56/167) in itraconazole, 29% (10/35) in terbinafine and 86% (6/7) in fluconazole. Cure rates after 2 year of treatment were 33% (17/51) in itraconazole, 8% (1/12) in terbinafine. Cure rates after 3 year of treatment were 29% (9/31) in itraconazole, 10% (1/10) in terbinafine.

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The 15 th Congress of the International Society for Human and Animal Mycology
    • ISHAM 15th (2003)