The wealth of whole genome data now available within the ascomycete branch of fungi is able to speed the process and improve the quality of annotation. Here we utilize the close relationship of Neurospora crassa and Aspergilus nidulans to annotate and analyze the newly sequenced Trichoderma reesei genome. W e aligned genetic markers from N. crassa and A.nidulans to each other and to T. reesei to search for syntenic regions that are conserved between two of the species or are conserved in all three of the species. Once identified these regions allow for the verification of genes based on position in the syntenic regions and other non-coding elements in the identified syntenic blocks to be verified by position as well as the standard amino-acid similarity. The creation of a database that include such large conserved regions will enrich our understanding of how genomes evolve or change over time, and will increase our knowledge of regions and motifs involved in regulation of gene transcription.
Full conference title:
23rd Fungal Genetics Conference
- Fungal Genetics Conference 23rd (2002)