Late Breaking Abstract: The effect of general anaesthesia in children with cystic fibrosis A pilot study

Chetan Pandit, Roume Valentin, Jonathan DeLima,1 Paul Robinson, Dominic Fitzgerald, Peter Cooper, Peter Van Asperen, David Baines, Hiran Selvadurai.

Author address: 

1Respiratory and Cystic Fibrosis, Childrens Hospital of Westmead, Sydney, NSW, Australia


Introduction Children with cystic fibrosis (CF) often receive general anaesthesia (GA) for a variety of different procedures. The few studies that have evaluated the risk of GA in children with CF are historical (1, 2) and report a high risk of morbidity. There is a paucity of data evaluating the risk of currently available anaesthetic agents in children with CF. The aim of this study was to assess the effect of GA on lung function and clinical status (using a validated CF clinical score) in children with CF. Methods Children with CF aged 6-18 years admitted for IV antibiotic treatment of a pulmonary exacerbation were invited to participate. Spirometry, Forced oscillatory technique (FOT) resistance and reactance and CF clinical score (CFCS) were measured pre-, and at 24 and 48 hours post-GA. The exact nature and duration of the GA were also recorded Children who were admitted with a pulmonary exacerbation but did not require GA to site a PICC line were also recruited and served as the control group. Data was analysed using a paired t-test (2 tailed) and p

abstract No: 


Full conference title: 

20th European Respiratory Society conference
    • ERS 20th (2010)