Invasive pulmonary aspergillosis in patients with underlying lung diseases in Saint Petersburg, Russia

N. V. Vasilyeva1, Y.V. Borzova1, E.A. Desyatik1, S.N. Khostelidi1, T.A. Stepanenko2, M.O. Popova3, R.M. Chernopyatova1, T.S. Bogomolova1, S.M. Ignatyeva1, O.A. Shurpitskaya1, A.S. Kolbin4, I.S. Zjuzgin5, N.I. Zubarovskaja6, N.V. Medvedeva6, A.V. K

Author address: 

Medical Academy for Postgraduate Education,Russian Federation, 2City Multifield Hospital Nr.2, Russian Federation, 3Institute of Children’s Hematology and Transplantology named R.M.Gorbacheva, Russian Federation, 4Pediatric City Hospital Nr.1, Ru

Abstract: 

Objectives: To define demographic parameters, underlying diseases, etiology, clinical features and survival rate of invasive pulmonary aspergillosis (IPA) in patients with lung diseases in St. Petersburg, Russia. Methods: The study was retrospective and multicentral. The diagnosis of IPA was established with EORTC / MSG 2008 criteria. Results: The study included 262 patients with IPA, registered between 1998 and 2010 in 19 hospitals in St. Petersburg. Underlying lung diseases (chronic obstructive pulmonary disease, tuberculosis, pulmonary silicosis, histiocytosis X, pulmonary sarcoidosis, pulmonary alveolar proteinosis and cystic fibrosis) were revealed in 18 (7%), hematological malignancies - in 232 (88%) patients with IPA. Twelve patients had various underlying diseases (disease of connective tissue, solid tumors). In the group of patients with underlying lung diseases the ratio of men and women was 2:1; median age 48 ± 4 years; in patients with hematological malignancies - 1,3:1; median age 37 ± 1.2 years. Major risk factors for IPA in patients with underlying lung disease vs. hematological malignancy were: prolonged corticosteroid therapy (mean duration 15 days vs. 3 days, P
2011

abstract No: 

P119

Full conference title: 

Trends in Medical Mycology, 5th
    • TIMM 5th (2013)