Invasive fungal infections (IFI) after allogeneic peripheral blood stem cell transplantation (PBSCT). Incidence and risk factors in 395 patients

R Martino, S Brunet, M Subiri, M Rovira, C Solano, L Vazquez, R De la Camara.


IFI are important infectious complications in recipients of allogeneic hematopoietic stem cell transplantation. We have retrospectively studied the incidence and risk factors for IFI among 395 adults who underwent an allogeneic PBSCT from an HLA-identical sibling in 15 centers in Spain from 1996 to 2000. 162 pts received a myeloablative unmanipulated PBSCT, 162 a T-cell-depleted myeloablative P13SCT and 71 a reduced-intensity unmanipulated PBSCT IFI were classified as possible, probable and definite according to the EORTC/IMISG definitions. There were 50 cases of IFI among 46 pts (4 pts developed 2 IFI): 12 cases of candidiasis, 32 aspergillosis and 6 other non-candida infections. Invasive candidiasis included 9 cases of uncomplicated candidemia and 3 visceral infections. The median day of onset of candidiasis was +28 (range +2-+157) post-transplant, and the implicated species were 8 C. albicans, 2 C. glabrata, 1 C. krusei and 1 Candida sp. One patient died from candidiasis. The probability of developing a non-candida IFI was 12%, and the median day of onset was +90 (range +4-+522) post-transplant (7 cases day +90). Mold infections included 10 cases of possible aspergillosis, 7 probable cases and 15 definite cases; 3 mucormycosis, 1 fusariosis and 1 penicillinosis (the 37 non-candida infections also included 1 disseminated cryptococcosis). 22 patients (59%) with a non-candida IFI died. In multivariate analysis two factors were associated with the occurrence of a non-candida IFL development of moderate-to-severe GVHD (RR 5.7,27-12, P

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Full conference title: 

Trends in Invasive fungal Infections 6, 2001
    • TIFI 6th