Invasive Fungal Infections after Allogeneic Peripheral Blood Stem Cell Transplantation. Incidence and Risk Factors in 395 Patients.

Rodrigo Martino, Maricel Subira, Montserrat Rovira, Carlos Solano, Lourdes Vazquez, Guillermo F. Sanz, Alvaro Urbano-Ispizua, Salut Brunet, Rafael De la Camara.

Author address: 

Hospital de Sant Pau, Barcelona; Hospital Clinico de Barcelona; Hospital Clinico de Valencia; Hospital Clinico de Salamanca; Hospital La Fe, Valencia; Hospital de la Princesa, Madrid, Spain

Abstract: 

We have analysed the incidence and risk factors for the occurrence of invasive fungal infections (IFI) among 395 recipients of an allogeneic peripheral blood stem cell transplantation (PBSCT) from an HLA-identical sibling. Fifty cases of an IFI occurred in 46 patients, for an overall probability of 14%. There were 12 cases of invasive candidiasis (3%), with only one death. Non-Candida IFI occurred in 37 patients (12% probability), mostly invasive aspergillosis (n=32). In multivariate analysis the only two significant variables associated with a higher risk of developing a non-Candida IFI were the development of moderate-to-severe GVHD (P
2001

abstract No: 

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Full conference title: 

43rd American Society of Hematology (ASH) Annual Meeting
    • ASH 43rd (2001)