Invasive fungal infection following allogenic haematopoietic stem cell transplantation adult versus children (single- centre experience)

M. Popova, N. Zubarovskaya, V. Vavilov, A. Volkova, M. Averjanova, N. Klimko, B. Afanasyev

Author address: 

I.P. Pavlov State Medical University (St. Petersburg, RU)

Abstract: 

Background: Invasive fungal infection (IFI) is a common cause of morbility and mortality in patients undergoing HSCT. Only 25% IFI diagnosed while alive. The aim. To compare incidence, risk factors of IFI in adults and children after allogenic (allo), haploidentical (haplo) HSCT. Patients: 236 patients (pts) were enrolled between 2000 and 2009. The adult group was 106 pts, age 21-68 (median 33 y.o.), the children group 130 pts, age 1-21 (median 14 y.o.) suffered from acute leukemias - 167, myelo- and lymphoproliferative disorders - 31, lymphomas - 18, inherent disorders - 8, others - 12. At the moment of HSCT in remission were 144, in relapse - 92. The most pts were received allo-HSCT as salvage therapy. Type of the donor: MRD - 130, MURD - 97, haploidentical donor - 9. MAC used in 85, RIC in 151. Sources of HSC: PBSC-154, BM-71, BM + PBSC-11. Median CD34 + - 3-8 x 10 6 /kg. Acute GvHD prophylaxis was CsA + short course of MTX or tacrolimus + MMF, plus ALG-60 mg/kg for MUD and haplo-HSCT. Results: The incidence of IFI following allo-HSCT was 32%. Possible IFI was detected in 30 (40%), probable IFI in 40 (53,4%) and proven IFI in 5 (6,6%) according to the international defi nition criteria EORTC/MSG 2008. Median date of IFI onset was D + 68 (1-940). The main causes of IFI were Aspergillus spp. 94%, Candida spp. 3%, Cryptococcus spp. 4%. The following risk factors were detected: in adults - usage of RIC, ATG, development of mucositis (P
2010

abstract No: 

P769

Full conference title: 

Annual Meeting of the EBMT, 36th
    • EBMT 36th (2010)