Invasive Aspergillosis Related to Construction and the Utility of Air Sampling.



A 8-bed Bone Marrow Tranplantation Unit (BMTU) opened in May of 1994. In August and September of 1995, 2 patients residing in the BMTU developed invasive srpergillosis. These cases occurred at the time when a major construction project was taking place on the floor directly below the unit. Review of the mycology log showed an additional 5 patients colonized with aspergillus in the units adjacent to the construction site within these two months. Aspergillus infection/colonization occurred at an average rate of 1.8 cases /month. There were 5 cases in September. Air sampling was performed in the BMTU, hematology/oncology waiting room, radiation therapy suite, and operating rooms before and after extensive room and air duct cleaning. The BMTU was closed to patients for 2 weeks. Aspergillus spore count as high as 0.7, 0.5, and 0.1 cfus/cu. mm were found in the BMTU, hematology/oncology waiting room and OR room 8 (where these two patients had their surgeries) before cleaning to undetectable after cleaning and changing of the ceiling tiles as in the case of OR 8. Additional infection control measures were implemented. Construction ceased in October and there were no furhter isolation of aspergillus in the BMTU or the units adjacent to the previous construction site for the next 8 months. This increase in aspergillus cases was temporarily related to construction which might have been responsible for the high aspergillus count on air sampling.

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39th Interscience Conference on Antimicrobial Agents and Chemotherapy
    • ICAAC 39th