Invasive aspergillosis in liver transplant recipients in the antifungal targeted prophylaxis era

I. Hoyo, C. Cervera, M. Bartoletti, G. Sanclemente, L. Linares, J. Puig de la Bellacasa, J. Colmenero, A. Escorsell, M. Navasa, A. Moreno*

Author address: 

Barcelona, ES)


Background: Invasive aspergillosis is a devastating complication affecting liver transplantation. Risk factors have been widely described and the use of antifungal prophylaxis seems to be justified in high-risk scenarios. Our aim is to evaluate the characteristics and incidence of IA in the era of antifungal targeted prophylaxis. Methods: All liver transplants recipients from July 2003 to December 2009 were included. Pre, peri and post-transplant variables were reviewed. Proven or probable invasive aspergillosis was defined according to the EORTC/MSG. Categorical variables were compared with the chi-square test or Fischer’s exact test. Backward step logistic regression analysis was used for multivariate analysis. Results: A total of 556 patients were evaluated. Overall, 135 patients (24%) fulfilled criteria of high-risk LT, in whom 57 (42%) antifungal prophylaxis was administered. In the study period, 16 patients developed IA (3%) with mortality related to IA in eight patients (50%). According to the presence of risk factors, 8.1% of high-risk LT developed IA vs 1.2% of patients without risk factors (p

abstract No: 


Full conference title: 

22nd European Congress of Clinical Microbiology and Infectious Diseases
    • ECCMID 22nd (2012)