A 10 year-old boy was diagnosed with acute lymphoblastic leukaemia in July 2003. Invasive aspergillosis initially presented as a cyst which in due course evolved to invasive cerebral aspergillosis. The patient was treated with voriconazole – despite monitoring of plasma levels, the optimal dose was quite difficult to determine. Low voriconazole levels required the dose to be progressively increased. He developed cerebral aspergillosis on oral voriconazole, and was controlled on oral posaconazole and IV caspofungin, with gamma interferon subcutaneously, after a short period on AmBisome. Currently he remains on oral posaconazole.
- Aspergillus fumigatus