Infectious Complications in Patients Treated for Hematological Malignancies

C. Orasch J6rg*, M. Weisser, A. Widmer, M. Battegay, S. Christen, D. Helm, A. Gratwoht, U. Ftuckiger.

Author address: 

Division of Infectious Diseases Et Hospital Epidemiology, University Hospital Basel, Switzerland


Background: Infections are a reading cause of comptications in patients treated with high-dose chemotherapy and/or hematopoietic stem cett transptantation (HSCT) for hematotogicat matignancies. Methods: In a prospective observationat cohort study we recorded art btoodstream infections (BSI) and art new putmonary infittrates in patients hospitatized at the Hematotogic Reverse Isotation Unit of the University Hospitat Base[ from Jury 2003 untit June 2005. Putmonary infittrates were separated into bacteriat or fungat pneumonia according to microbiotogicat and radiotogicat findings. Invasive aspergillosis (IA) was ctassified as proven, probabte or possibte according to EORTC/MSG consensus definitions. Results: From Jury 2003 to June 2005, 160 patients with 249 episodes of hospitatization were included. 91 (36%) episodes occurred during attogeneic HSCT, 40 (16%) to autotogous HSCT and 118 (47%) to induction/consotidation chemotherapies. We noted 44 (18%) episodes of BSI (incidence 13.8/1000 days of neutropenia), 53 (21%) episodes of pneumonia (incidence 17.3/1000 days of neutropenia) and 35 (14%) episodes of IA (26 possibte, 5 probabte, 4 proven). IA occurred in 15/95 (16.5%) attogeneic HSCTs, in 16/118 (16%) chemotherapies and in onty 1/40 (2.6%) episodes of autotogous HSCT. The highest incidence of infectious comptications was seen in patients undergoing attogeneic HSCT (59/91, 65%), fottowed by patients receiving high-dose chemotherapies (58/118, 49%) and [owest after autotogous HSCT (12/40, 30%). Overatt in-hospitat mortatity was 13%; 12% in attogeneic HSCT, 8% in chemotherapies and 0% in autotogous HSCT. Conclusion: The incidence of BSI was tower than reported in the titerature, possibty retated to the routine use of chtorhexidine-suffadiazinecoated catheters. The incidence of pneumonia was higher probabty because of the regutarty performed CT scans. However, the IA rate was comparabte to the titerature.

abstract No: 


Full conference title: 

14th International Symposium of Infections in the Immunocompromised Host
    • ISIIH, 14th