Two Scedosporium species are known to cause opportunistic infections in humans: Scedosporium apiospermum (teleomorph: Pseudallescheria boydii) and S. prolificans (teleomorph: unknown). Both species occur world-wide in agricultural soil and in polluted water and sewage. Clinical manifestations of scedosporioses have a broad spectrum from subcutaneous to disseminated diseases. Due to multidrug resistance, treatment possibilities are insufficient. This often leads to the death of patients with systemic scedosporiosis. Presently, complete surgical resection (if possible) combined with antimycotic therapy (itraconazole or voriconazole and terbinafine) seems to be the treatment of choice. Herewith, we give an overview of six cases of scedosporiosis diagnosed in Bonn between 1998 and 2002. All cases were confirmed by repeated isolation of the fungi from primarily sterile specimens and/or by histopathology. The species identification were confirmed by ITS rDNA-sequencing.
Full conference title:
14th Annual Focus on Fungal Infections
- FFI 14th (2004)